serine/threonine protein kinase Nek1; never in mitosis A-related kinase 1; NimA-related protein kinase 1; renal carcinoma antigen NY-REN-55 (NEK1, KIAA1901)

Function

• phosphorylates Ser & Thr
• also appears to possess tyrosine kinase activity
• implicated in control of meiosis (putative)
• role in cilium assembly
• binds to SPERT (putative)

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
• contains 1 protein kinase domain

Compartment

• nucleus (probable), cytoplasm, cytoskeleton, centrosome (putative)
• associated with the pericentriolar material
• localizes to centrosome during interphase & mitosis (putative)

Alternative splicing

named isoforms=5

Expression

high fetal expression in the brain & kidney

Pathology

• defects in NEK1 are the cause of short rib-polydactyly syndrome type 2

More general terms

• serine/threonine protein kinase NEK
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4750
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4750
• OMIM: https://mirror.omim.org/entry/263520
• OMIM: https://mirror.omim.org/entry/604588
• UniProt: http://www.uniprot.org/uniprot/Q96PY6.html