RNA 3'-terminal phosphate cyclase; RNA cyclase; RNA-3'-phosphate cyclase; RNA terminal phosphate cyclase domain-containing protein 1; RTC domain-containing protein 1 (RTCD1, RTC1, RTCA)

Function

• catalyzes conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA
• the mechanism of action of the enzyme occurs in 3 steps:
  • adenylation of the enzyme by ATP
  • transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A
  • attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product
• the biological role unknown
• likely to function in some aspects of cellular RNA processing

ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate

Structure

• monomer
• belongs to the RNA 3'-terminal cyclase family, type 1 subfamily

Compartment

nucleus, nucleoplasm

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• adenosine triphosphatase (ATPase)
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8634
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8634
• OMIM: https://mirror.omim.org/entry/611286
• UniProt: http://www.uniprot.org/uniprot/O00442.html