TP53-regulating kinase; Nori-2; p53-related protein kinase (TP53RK, C20orf64, PRPK)

Function

• protein kinase that phosphorylates Ser-15 of p53/TP53 protein & may therefore participate in its activation
• interacts with TPRKB

ATP + a protein = ADP + a phosphoprotein

Structure

• belongs to the protein kinase superfamily
• contains 1 protein kinase domain

Compartment

nucleus

Expression

• expressed in testis > heart, kidney, spleen

More general terms

• serine/threonine kinase
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=112858
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:112858
• OMIM: https://mirror.omim.org/entry/608679
• UniProt: http://www.uniprot.org/uniprot/Q96S44.html