cyclophilin D (cyclophilin 40, 40 kD peptidyl-prolyl cis-trans isomerase, PPID, CYP40, CYPD)

Function

• PPIases accelerate the folding of proteins
• catalyzes cis-trans isomerization of proline imidic peptide bonds in oligopeptides
• binds ESR1 (putative)
• less sensitive to inhibition by cyclosporin A than is CYP-18

peptidylproline (omega=180) <--> peptidylproline (omega=0)

Structure

• belongs to the cyclophilin-type PPIase family, PPIase D subfamily
• contains 1 PPIase cyclophilin-type domain contains 3 TPR repeats

Compartment

cytoplasm

Expression

widely expressed

More general terms

• cyclophilin
• chaperonin; chaperone
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q08752.html
• OMIM: https://mirror.omim.org/entry/601753
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5481