von Willebrand factor A domain-containing protein 2 (A domain-containing protein similar to matrilin & collagen, AMACO, colon cancer secreted protein 2, CCSP-2, VWA2, AMACO)

Structure

• contains 2 EGF-like domains
• contains 3 VWFA domains
• forms monomers & multimers (putative)
• 55 kD form is produced by proteolytic cleavage

Compartment

secreted

Alternative splicing

named isoforms=3

Expression

• expression is generally absent in normal colon & other normal body tissues

Pathology

• induced an average of 78-fold in Stage II, III, & IV colon cancers, as well as in colon adenomas & colon cancer cell lines

Notes

serological marker for colon neoplasia

More general terms

• secreted protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5GFL6.html