dermcidin (preproteolysin, [Contains: Survival-promoting peptide; DCD-1], DCD, AIDD, DSEP)

Function

• DCD-1 displays antimicrobial activity, limiting skin infection by potential pathogens in the first few hours after bacterial colonization
• highly effective against E. coli, E. faecalis, S. aureus & C. albicans.
• optimal pH & salt concentration resemble the conditions in sweat
• survival-promoting peptide promotes survival of neurons & displays phosphatase activity
• may bind IgG

Cofactor: Mn+2 required for survival-promoting peptide

Compartment

• secreted into the sweat at a concentration of 1-10 ug/mL

Expression

• specifically & constitutively expressed in eccrine sweat glands

More general terms

• secreted protein

Database

• OMIM: https://mirror.omim.org/entry/606634
• UniProt: http://www.uniprot.org/uniprot/P81605.html