keratan sulfate proteoglycan keratocan

Function

• developing & maintaining corneal transparency & for the structure of the stromal matrix
• binds keratan sulfate chains

Structure

• belongs to the small leucine-rich proteoglycan (SLRP) family, SLRP class II subfamily
• contains 10 LRR repeats (leucine-rich repeats)
• contains 1 LRRNT domain

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Expression

• cornea
• trachea
• low levels in intestine, skeletal muscle, ovary, lung & putamen

Pathology

• mutations associated with autosomal recessive cornea plana 2
• increased expression in keratoconus

More general terms

• keratan sulfate proteoglycan
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11081
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11081
• OMIM: https://mirror.omim.org/entry/217300
• OMIM: https://mirror.omim.org/entry/603288
• UniProt: http://www.uniprot.org/uniprot/O60938.html