phospholipase-A2 [PLA2] type 3 (Ca+2-dependent PLA2, bee venom phospholipase-A2, phosphatidylcholine 2-acylhydrolase, PLA2-10, group V phospholipase A2, PLA2G5)
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Function
- PA2 catalyzes Ca+2-dependent hydrolysis of 2-acyl groups in 3-sn-phosphoglycerides
- hydrolyzes L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine more efficiently than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L- alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol
- may be involved in
- production of lung surfactant,
- remodeling or regulation of cardiac muscle
phosphatidylcholine + H2O
<-->
1-acylglycerophosphocholine + a carboxylate
Cofactor: binds 1 Ca+2 per subunit (putative)
Kinetic parameters:
- Optimum pH is 6.5, activity remains high up to pH 9.0
Structure
- belongs to the phospholipase A2 family
- acks one of 7 disulfide bonds found in similar PA2 proteins
Compartment
Expression
heart, placenta > lung
More general terms
References
- ↑ Mayer RJ, Marshall LA. New insights on mammalian phospholipase A2(s); comparison of arachidonoyl-selective and -nonselective enzymes. FASEB J. 1993 Feb 1;7(2):339-48. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8440410
- ↑ Glaser KB, Mobilio D, Chang JY, Senko N. Phospholipase A2 enzymes: regulation and inhibition. Trends Pharmacol Sci. 1993 Mar;14(3):92-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8488570
- ↑ UniProt http://www.uniprot.org/uniprot/P39877.html