H/ACA ribonucleoprotein complex subunit 2 (nucleolar protein family A member 2, snoRNP protein NHP2, NOLA2, NHP2, HSPC286)

Function

• required for ribosome biogenesis & telomere maintenance
• component of H/ACA small nucleolar ribonucleoprotein complex (H/ACA snoRNP complex)
• may be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
• associates with NOLC1/NOPP140

Structure

belongs to the ribosomal protein L7Ae family

Compartment

• nucleus, nucleolus, Cajal body
• localized to Cajal bodies (coiled bodies)

Expression

• expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus > liver
• transcript peaks at G1/S transition

More general terms

• protein subunit

Component of

• H/ACA small nucleolar ribonucleoprotein complex (H/ACA snoRNP complex)

Database

• OMIM: https://mirror.omim.org/entry/606470
• UniProt: http://www.uniprot.org/uniprot/Q9NX24.html