exocyst complex component 2; exocyst complex component sec5 (EXOC2, SEC5, SEC5L1)

Function

• component of the exocyst complex involved in docking of exocystic vesicles with fusion sites on the plasma membrane
• interacts with RALA & GNEFR/DELGEF
• interaction with GNEFR occurs only in the presence of Mg+2 or Mn+2 & is stimulated by dCTP or GTP
• interacts with RALB

Structure

• interacts with RALA through the TIG domain
• belongs to the SEC5 family
• contains 1 IPT/TIG domain

Expression

• widely expressed
• highest levels in brain & placenta

More general terms

• protein subunit
• phosphoprotein

Component of

• exocyst complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55770
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55770
• UniProt: http://www.uniprot.org/uniprot/Q96KP1.html