anti-rheumatoid arthritis-associated antigen (RANA)

Etiology

• originally found in patients with
  • Sjogren's syndrome
  • rheumatoid arthritis
• the antigen is also detected in B cells infected with Epstein Barr virus

Pathology

• nuclear distribution in a finely speckled pattern by immuno-fluorescence microscopy.

Clinical significance

• anti-RANA is detected in 90% of patients with rheumatoid arthritis & in 6-25% of control subjects

More general terms

• autoantibody

Additional terms

• rheumatoid arthritis (RA)
• Sjogren's syndrome (autoimmune epitheliitis)