mitochondrial import inner membrane translocase subunit TIM50 (TIMM50, TIM50, PRO1512)

Function

• essential component of the TIM23 complex
• has some phosphatase activity in vitro; however may not be relevant in vivo
• isoform 2 may participate in the release of snRNPs & SMN from the Cajal body
• isoform 2 interacts with COIL & snRNPs

Structure

• belongs to the TIM50 family
• contains 1 FCP1 homology domain
  • domain does not contain the canonical D-x-D-x-[TV] active site, thus probably does not have phosphatase activity

Compartment

• mitochondrial inner membran
• isoform 2: nucleus speckle nuclear & enriched in speckles with snRNPs

Alternative splicing

named isoforms=2

Expression

• widely expressed
• strong expression in brain, kidney, liver

More general terms

• protein subunit
• mitochondrial membrane protein

Component of

• mitochondrial import inner membrane translocase subunit (TIM, translocase of inner mitochondrial membrane, mitochondrial protein importer)
• TIM23 complex

Database

• OMIM: https://mirror.omim.org/entry/607381
• UniProt: http://www.uniprot.org/uniprot/Q3ZCQ8.html