mitochondrial import inner membrane translocase subunit TIM22 (testis-expressed sequence 4, TIMM22, TEX4, TIM22)

Function

• essential core component of the TIM22 complex
• in the TIM22 complex, it constitutes the voltage-activated & signal-gated channel
• forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps
• interacts directly with TIMM9, TIMM10/TIM10A & FXC1/TIM10B

Structure

belongs to the Tim17/Tim22/Tim23 family

Compartment

mitochondrial inner membrane

More general terms

• protein subunit
• transmembrane 3 protein
• mitochondrial membrane protein

Component of

• mitochondrial import inner membrane translocase subunit (TIM, translocase of inner mitochondrial membrane, mitochondrial protein importer)
• TIM22 complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2992
• OMIM: https://mirror.omim.org/entry/607251
• UniProt: http://www.uniprot.org/uniprot/Q9Y584.html