mitochondrial import inner membrane translocase subunit TIM9B (fracture callus protein 1, FxC1, TIM10B)

Function

• component of the TIM22 complex
• in the TIM22 complex, it may act as a docking point for the soluble 70 kD complex that guides target proteins in transit through the mitochondrial intermembrane space

Structure

• the twin CX3C motif contains 4 conserved Cys that form 2 disulfide bonds in the mitochondrial intermembrane space
• however, during the transit of FXC1/TIM10B from cytoplasm into mitochondrion, the Cys probably coordinate Zn+2, thus preventing folding & allowing its transfer across the mitochondrial outer membrane (putative)
• belongs to the small Tim family

Compartment

mitochondrial inner membrane

Expression

• ubiquitous
• highest expression in heart, kidney, liver & skeletal muscle

More general terms

• protein subunit
• mitochondrial membrane protein

Component of

• mitochondrial import inner membrane translocase subunit (TIM, translocase of inner mitochondrial membrane, mitochondrial protein importer)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2651
• OMIM: https://mirror.omim.org/entry/607388
• UniProt: http://www.uniprot.org/uniprot/Q9Y5J6.html