Hsp70-binding protein 1 (HspBP1, heat shock protein-binding protein 1, Hsp70-interacting protein 1, Hsp70-binding protein 2, HspBP2, Hsp70-interacting protein 2, HSPBP1, HSPBP, PP1845)

Function

• inhibits HSPA1A chaperone activity by changing conformation of the ATP-binding domain of HSPA1A & interfering with ATP binding
• interferes with ubiquitination mediated by STUB1 & inhibits chaperone-assisted degradation of immature CFTR
• interacts with the ATP-binding domain of HSPA1A
• detected in a ternary complex containing STUB1, HSPA1A & HSPBP

Structure

contains 4 ARM repeats

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NZL4.html