epsin-3 (EPS-15-interacting protein 3, EPN3)

Function

• wound healing (putative)
• binds phosphatidylinositol lipid headgroup

Structure

• belongs to the epsin family
• contains 1 ENTH domain (epsin N-terminal homology domain)
• contains 2 UIM repeats (ubiquitin-interacting motif repeats)

Compartment

• cytoplasm, perinuclear region, clathrin-coated vesicle, nucleus
• concentrated in the perinuclear region & associated with clathrin-coated vesicles close to the cell periphery
• may shuttle to the nucleus

Alternative splicing

named isoforms=2

Expression

• detected in migrating keratinocytes from wounded skin, but not in differentiating keratinocytes or in normal skin
• induced in keratinocytes, by wounding or contact with collagen

Pathology

• detected in chronic wounds, basal cell carcinoma & ulcerative colitis

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/607264
• UniProt: http://www.uniprot.org/uniprot/Q9H201.html