angiogenic factor with G patch & FHA domains 1 (angiogenic factor VG5Q, vasculogenesis gene on 5q protein, hVG5Q, AGGF1, VG5Q)

Function

• promotes angiogenesis & proliferation of endothelial cells
• binds to endothelial cells & promotes cell proliferation
• autocrine agent
• interacts with the secreted angiogenic factor TNFSF12

Structure

• contains 1 FHA domain contains 1 G-patch domain

Compartment

• cytoplasm, secreted, cytoplasmic in microvascular endothelial cells secreted upon initiation of endothelial cell tube formation during angiogenesis

Alternative splicing

named isoforms=3

Expression

• widely expressed
• expressed in endothelial cells, vascular smooth muscle cells & osteoblasts
• expressed in umbilical vein endothelial cells & microvascular endothelial cells

Pathology

• defects in AGGF1 are a cause of Klippel-Trenaunay syndrome

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/149000
• OMIM: https://mirror.omim.org/entry/608464
• UniProt: http://www.uniprot.org/uniprot/Q8N302.html