SCY1-like protein 1 (N-terminal kinase-like protein, teratoma-associated tyrosine kinase, telomerase transcriptional element-interacting factor, telomerase regulation-associated protein, SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP, HT019)

Function

• isoform 6 acts as transcriptional activator
• isoform 6 binds to three different type of GC-rich DNA binding sites (box-A, box-B, & box-C) in the beta-polymerase promoter region
• isoform 6 binds also to the TERT promoter region
• no detectable kinase activity in vitro
• interacts with SCYL1BP1
• homooligomer

Structure

• contains 3 HEAT repeats
• contains 1 protein kinase domain, predicted catalytically inactive Centrosome, cytoplasm, nucleus

Alternative splicing

named isoforms=6

Expression

ubiquitous

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/607982
• UniProt: http://www.uniprot.org/uniprot/Q96KG9.html