non-homologous end-joining factor 1 (protein Cernunnos, XRCC4-like factor, NHEJ1, XLF)

Function

• DNA repair protein involved in DNA nonhomologous end joining in DNA double-strand break repair & V(D)J recombination
• bridge between XRCC4 & other factors located at DNA ends
• interacts with XRCC4

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

ubiquitously expressed

Pathology

• defects in NHEJ1 are a cause of combined immune deficiency

Notes

• named 'Cernunnos' after the Celtic god of hunt, underworld & fertility

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H9Q4.html