Ras-related & estrogen-regulated growth inhibitor (RERG)

Function

• binds GDP/GTP
• intrinsic GTPase activity
• higher affinity for GDP than for GTP
• in cell lines, overexpression inhibits proliferation, colony formation & tumorigenic potential.

Compartment

cytoplasm

Expression

• expressed in heart, brain, placenta, lung, liver, skin, kidney, pancreas
• expressed in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines
• up-regulated by estradiol
• down-regulated by tamoxifen

Pathology

• loss of RERG expression may contribute to breast cancer
• RERG expression is decreased or lost in a significant proportion of primary breast cancer with poor clinical prognosis
• high expression of RERG correlates with long relapse-free survival times in patients with breast cancer

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96A58.html