metastasis suppressor protein 1; missing in metastasis protein; metastasis suppressor YGL-1 (MTSS1, MIM, KIAA0429)

Function

• may be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton
• binds to actin
• binds to the cytoplasmic domain of receptor-type tyrosine phosphatase delta (PTPRD)

Structure

• the WH2 motif at the C-terminus binds to actin monomers
• belongs to the MTSS1 family
• contains 1 IMD (IRSp53/MIM homology) domain
• contains 1 WH2 domain

Compartment

cytoplasm, cytoskeleton

Alternative splicing

named isoforms=3

Expression

• expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, & peripheral blood

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9788
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9788
• OMIM: https://mirror.omim.org/entry/608486
• UniProt: http://www.uniprot.org/uniprot/O43312.html