ubiquinone biosynthesis protein COQ7 homolog; coenzyme Q biosynthesis protein 7 homolog; timing protein clk-1 homolog (COQ7)

Function

• role in lifespan determination (ubiquinone-independent)
• role in ubiquinone biosynthesis
• central metabolic regulator (putative)
• cofactor biosynthesis; ubiquinone biosynthesis

Cofactor: binds 2 iron ions per subunit (putative)

Structure

belongs to the COQ7 family

Compartment

• mitochondrial inner membrane
• peripheral membrane, matrix side
• synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off & the mature protein becomes loosely associated with the inner mitochondrial membrane (putative)

Alternative splicing

named isoforms=2

Expression

• expressed dominantly in heart & skeletal muscle

Pharmacology

• clioquinol inhibits the activity of mammalian COQ7 in cultured cells
  • inhibition that can be blocked by Fe+2 or Co+2

More general terms

• mitochondrial protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10229
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10229
• OMIM: https://mirror.omim.org/entry/601683
• UniProt: http://www.uniprot.org/uniprot/Q99807.html