cancer/testis antigen 2; CT2; L antigen family member 1; LAGE-1; autoimmunogenic cancer/testis antigen NY-ESO-2; cancer/testis antigen 6.2; CT6.2 (CTAG2, ESO2, LAGE1)

Structure

• isoform LAGE-1A contains a transmembrane domain
• belongs to the CTAG family

Compartment

• isoform LAGE-1A: membrane; single-pass membrane protein (putative)

Alternative splicing

named isoforms=2; LAGE-1B; LAGE-1A

Expression

• expressed in testis
• expresses in very low level in placenta & in some uterus samples

Pathology

• expression observed in 25-50% of tumor samples of
  • melanoma
  • non-small-cell lung carcinoma
  • bladder cancer
  • prostate cancer
  • head & neck cancer

More general terms

• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=30848
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:30848
• OMIM: https://mirror.omim.org/entry/300396
• UniProt: http://www.uniprot.org/uniprot/O75638.html