Tau-tubulin kinase 2 (TTBK2, KIAA0847)

Function

• serine/threonine protein kinase
• phosphorylates microtubule-assciated protein tau on Ser

Structure

• belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family
• contains 1 protein kinase domain

Alternative splicing

named isoforms=3

Pathology

• defects in TTBK2 are the cause of spinocerebellar ataxia type 11

More general terms

• serine/threonine kinase

Additional terms

• ubiquitin-like PHD & RING finger domain-containing protein (UHRF)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=146057
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:146057
• OMIM: https://mirror.omim.org/entry/604432
• OMIM: https://mirror.omim.org/entry/611695
• UniProt: http://www.uniprot.org/uniprot/Q6IQ55.html