leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1, KIAA1790)

Function

• binding of GTP stimulates kinase activity

Cofactor: Mg+2, Mn+2

Structure

• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, ROCO subfamily
• contains 4 ANK repeats
• contains 13 LRR repeats (leucine-rich repeats)
• contains 1 protein kinase domain
• contains 1 Roc domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

More general terms

• serine/threonine kinase
• leucine-rich repeat-containing protein (LRRC)
• ankyrin repeat domain protein (ANKRD)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79705
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79705
• OMIM: https://mirror.omim.org/entry/610986
• UniProt: http://www.uniprot.org/uniprot/Q38SD2.html