mitogen-activated protein kinase kinase kinase DAPK2; DAP kinase 2; DAP-kinase-related protein 1; DRP-1 (DAPK2)

Function

• Ca+2/calmodulin-dependent serine/threonine kinase
• acts as a positive regulator of apoptosis
• autophosphorylation at Ser-318

Structure

• homodimer
  • homodimerization is required for apoptotic function & is inhibited by autophosphorylation at Ser-318

Compartment

cytoplasm

Expression

ubiquitously expressed

More general terms

• serine/threonine kinase
• oligomerizing protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UIK4.html