serine/threonine protein kinase Sgk3; serum/glucocorticoid-regulated kinase 3; serum/glucocorticoid-regulated kinase-like (SGK3, SGKL)

Function

• role in the activation of K+ channels
• mediates cell IL-3-dependent survival signals (putative)
• two specific sites, one in the kinase domain (Thr-320) & the other in the C-terminal regulatory region (Ser-486), need to be phosphorylated for its full activation

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family
• contains 1 AGC-kinase C-terminal domain
• contains 1 protein kinase domain
• contains 1 PX (phox homology) domain

Compartment

• cytoplasmic vesicle, early endosome (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in most tissues
• highest levels in pancreas, kidney liver, heart & brain
• lower levels in lung, placenta & skeletal muscle

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=100533
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23678
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:100533
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23678
• OMIM: https://mirror.omim.org/entry/607591
• UniProt: http://www.uniprot.org/uniprot/Q96BR1.html