serine/threonine protein kinase PRP4 homolog; PRP4 kinase; PRP4 pre-mRNA-processing factor 4 homolog (PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K)

Function

• role in pre-mRNA splicing
• phosphorylates SF2/ASF
• phosphorylated by Clk1
• identified in the spliceosome C complex
• interacts with Clk1 C-terminus

Structure

• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family
• contains 1 protein kinase domain

Compartment

nucleus

Expression

ubiquitous

More general terms

• serine/threonine kinase
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8899
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8899
• OMIM: https://mirror.omim.org/entry/602338
• UniProt: http://www.uniprot.org/uniprot/Q13523.html