serine/threonine protein kinase H1; H1 kinase; PSK-H1 (PSKH1)

Function

• may be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking & pre-mRNA processing
• activity depends on Ca+2 concentration
• autophosphorylated on Ser

Structure

• myristoylation required for membrane association & palmitoylation
• homodimer
• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family
• contains 1 protein kinase domain

Compartment

• Golgi; brefeldin A-sensitive Golgi compartment
• centrosome, nuclear speckle
• found to concentrate in splicing factor compartments within the nucleus of interphase cells
• endoplasmic reticulum membrane
• lipid-anchor, plasma membrane
• lipid-anchor, cytoplasm
• acylation-negative form may be only cytoplasmic & nuclear acylation seems to allow the sequestering to the intracellular membranes
• myristoylation may mediate targeting to the intracellular non-Golgi membranes & palmitoylation may mediate targeting to the Golgi membranes
• dual acylation is required to stabilize the interaction with Golgi membranes

Expression

• expressed in all tissues & cell lines tested with the highest level of abundance in testis

More general terms

• serine/threonine kinase
• myristoylated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5681
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5681
• OMIM: https://mirror.omim.org/entry/177015
• UniProt: http://www.uniprot.org/uniprot/P11801.html