bile salt-activated lipase; BAL; bile salt-stimulated lipase; BSSL; carboxyl ester lipase; sterol esterase; cholesterol esterase; pancreatic lysophospholipase (CEL)

Function

• catalyzes fat & vitamin absorption
• acts in concert with pancreatic lipase & colipase for the complete digestion of dietary triglycerides
• activated by bile salts containing a 7-hydroxyl group

triacylglycerol + H2O <--> diacylglycerol + carboxylate

steryl ester + H2O <--> sterol + fatty acid

Structure

belongs to the type-B carboxylesterase/lipase family

Alternative splicing

named isoforms=2

Expression

mammary gland & pancreas

Pathology

• defects in CEL are a cause of mature-onset diabetes of the young type 8 with exocrine dysfunction (MODY8)

More general terms

• lysophospholipase

Database

• UniProt: http://www.uniprot.org/uniprot/P19835.html
• OMIM: https://mirror.omim.org/entry/114840
• OMIM: https://mirror.omim.org/entry/606391