N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-hydrolyzing phospholipase D, NAPE-PLD, NAPEPLD, C7orf18)

Function

• hydrolyzes N-acyl-phosphatidylethanolamines to produce N-acylethanolamines & phosphatidic acid
• responsible for the generation of anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid & vanilloid receptors (putative)
• activity is stimulated by divalent cations

Cofactor: binds 1 or 2 Zn+2 per subunit (putative)

Structure

• monomer (putative)
• belongs to the NAPE-PLD family

Compartment

membrane (putative)

More general terms

• phospholipase-D (PLD)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2222
• UniProt: http://www.uniprot.org/uniprot/Q6IQ20.html