cathepsin-A (carboxypeptidase-C, lysosomal protective protein, vertebrate protective protein, CTSA, PPGB)

Function

• associates with beta-galactosidase & neuraminidase & exerts a protective function necessary for their stability & activity
• carboxypeptidase activity, can deamidate tachykinins
• release of a C-terminal amino acid with broad specificity

Structure

• heterodimer of a 32 kD chain & a 20 kD chain disulfide-linked
• belongs to the peptidase S10 family

Compartment

Lysosome

Pathology

• defects in CTSA are the cause of galactosialidosis

Laboratory

• cathepsin A in leukocytes

More general terms

• cathepsin
• carboxypeptidase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5476
• OMIM: https://mirror.omim.org/entry/256540
• UniProt: http://www.uniprot.org/uniprot/P10619.html