aminopeptidase B; AP-B; arginine aminopeptidase; arginyl aminopeptidase (RNPEP, APB)

Function

• exopeptidase which selectively removes Arg &/or Lys from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin & Arg(-1)-Lys(0)-somatostatin-14
• can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (putative)
• release of N-terminal Arg & Lys from oligopeptides when P1' is not Pro
• also acts on arylamides of Arg & Lys

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

belongs to the peptidase M1 family

Compartment

secreted (putative)

Expression

• expressed in liver & secreted

More general terms

• aminopeptidase
• secreted protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6051
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6051
• OMIM: https://mirror.omim.org/entry/602675
• UniProt: http://www.uniprot.org/uniprot/Q9H4A4.html