glutamyl aminopeptidase; EAP; aminopeptidase A; AP-A; differentiation antigen gp160; CD249 (ENPEP)

Function

• appears to have a role in the catabolic pathway of the renin-angiotensin system
• probably plays a role in regulating growth & differentiation of early B-lineage cells
• release of N-terminal Glu (& to a lesser extent Asp) from a peptide

Cofactor:

• binds 1 Zn+2 per subunit (putative)

Structure

• homodimer; disulfide-linked
• belongs to the peptidase M1 family

Compartment

• membrane; single-pass type 2 membrane protein

Expression

• expressed by epithelial cells of the proximal tubule & the glomerulus of the nephron
• also found in a variety of other tissues

More general terms

• zinc metalloprotease
• aminopeptidase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2028
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2028
• OMIM: https://mirror.omim.org/entry/138297
• UniProt: http://www.uniprot.org/uniprot/Q07075.html