CAAX prenyl protease 2; farnesylated proteins-converting enzyme 2; FACE-2; prenyl protein-specific endoprotease 2; RCE1 homolog; hRCE1 (RCE1 FACE2 RCE1A RCE1B)

Function

• proteolytically removes the C-terminal 3 residues of farnesylated & geranylated proteins
• seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B & G-gamma-1

Structure

belongs to the peptidase U48 family

Compartment

• endoplasmic reticulum membrane
• multi-pass membrane protein (putative)

Expression

ubiquitous

More general terms

• protease; proteinase; endopeptidase
• transmembrane 7 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9986
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9986
• OMIM: https://mirror.omim.org/entry/605385
• UniProt: http://www.uniprot.org/uniprot/Q9Y256.html