adiponectin receptor protein 1 (progestin & adipoQ receptor family member 1, ADIPOR1, PAQR1, CGI-45)

Function

• receptor for globular & full-length adiponectin
• involved in metabolic pathways that regulate lipid metabolism, i.e. fatty acid oxidation
• mediates increased AMPK, PPARA ligand activity, fatty acid oxidation & glucose uptake by adiponectin.
• high-affinity receptor for globular adiponectin
• low-affinity receptor for full-length adiponectin
• forms homo & heteromultimers

Compartment

• localized to the cell membrane & intracellular organelles
• widely expressed
• expressed in skeletal muscle > brain, heart, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes > colon, thymus, small intestine

More general terms

• transmembrane 7c protein
• progestin & adipoQ receptor (PAQR)

Additional terms

• adiponectin

Database

• OMIM: https://mirror.omim.org/entry/607945
• UniProt: http://www.uniprot.org/uniprot/Q96A54.html