folate receptor alpha; FR-alpha; folate receptor 1; folate receptor, adult; adult folate-binding protein; FBP; ovarian tumor-associated antigen MOv18; KB cells FBP (FOLR1, FOLR)

Function

• binds to folate & reduced folic acid derivatives
• mediates delivery of 5-methyltetrahydrofolate to the interior of cells
• secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, &/or by proteolysis catalyzed by a metalloprotease

Structure

• belongs to the folate receptor family
• 8 disulfide bonds are present (probable)

Compartment

• cell membrane; lipid-anchor, GPI-anchor
• secreted (probable)

Expression

• exclusively expressed in tissues of epithelial origin

Pathology

• expression is increased in malignant tissues

More general terms

• folate receptor or folate-binding protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2348
• OMIM: https://mirror.omim.org/entry/136430
• UniProt: http://www.uniprot.org/uniprot/P15328.html