Rho GTPase-activating protein 8 (ARHGAP8)

Function

• GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (putative)

Structure

• contains 1 CRAL-TRIO domain
• contains 1 Rho-GAP domain

Alternative splicing

named isoforms=3

Expression

• highly expressed in kidney & placenta
• also expressed in colon, skeletal muscle, small intestine, stomach, & testis
• not detected in brain, liver or spleen

Pathology

• overexpressed in majority of colorectal tumors examined

More general terms

• rho GTPase-activating protein (rho-GAP)

Database

• UniProt: http://www.uniprot.org/uniprot/P85298.html