Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein 6, RhoGAPX-1)

Function

• GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state
• could regulate interactions of signaling molecules with actin cytoskeleton
• promotes continuous elongation of cytoplasmic processes during cell motility & simultaneous retraction of cell body
• changing the cell morphology

Structure

contains 1 Rho-GAP domain

Compartment

cytoplasm

Alternative splicing

named isoforms=5

Expression

• expressed in kidney, heart & skeletal muscle > retina, lymphoblast, placenta, lung, brain, pancreas & liver

Genetics

• ARHGAP6 gene undergoes X inactivation

More general terms

• rho GTPase-activating protein (rho-GAP)

Database

• OMIM: https://mirror.omim.org/entry/300118
• OMIM: https://mirror.omim.org/entry/309801
• UniProt: http://www.uniprot.org/uniprot/O43182.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=395