septin-1; LARP; peanut-like protein 3; serologically defined breast cancer antigen NY-BR-24 (SEPT1, DIFF6, PNUTL3)

Function

• filament-forming cytoskeletal GTPase (putative)
• may play a role in cytokinesis (putative)
• Ser-248 & Ser-315 are probably phosphorylated by STK12
• septins polymerize into heterooligomeric protein complexes that form filaments
• the can associate with cellular membranes, actin filaments & microtubules
• GTPase activity is required for filament formation (putative)
• interacts with AURKB/STK12

Structure

• belongs to the septin family

Compartment

• cytoplasm (putative)
• cytoskeleton (putative)
• centrosome
• remains at the centrosomes & the nearby microtubules throughout mitosis
• localizes to the midbody during cytokinesis

Alternative splicing

named isoforms=2

Expression

• expressed at high levels in lymphoid & hematopoietic tissues

More general terms

• septin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1731
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1731
• OMIM: https://mirror.omim.org/entry/612897
• UniProt: http://www.uniprot.org/uniprot/Q8WYJ6.html