histone H2B type 1-A; histone H2B testis; testis-specific histone H2B (HIST1H2BA, TSH2B)

Function

• core component of nucleosome
• monoubiquitination of Lys-122 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation & is also prerequisite for histone H3 Lys-4 & Lys-79 methylation
• functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase 2

Structure

belongs to the histone H2B family

Compartment

nucleus

Expression

• transcribed exclusively in testis
• protein is present in mature sperm

More general terms

• histone-H2B
• testis-specific protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=255626
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:255626
• OMIM: https://mirror.omim.org/entry/609904
• UniProt: http://www.uniprot.org/uniprot/Q96A08.html