transcription factor HES-3 (hairy & enhancer of split 3)
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Function
- transcriptional repressor of genes that require a bHLH protein for their transcription
- transcription repression requires formation of complex with corepressor protein (Groucho)
Structure
- has a particular type of basic domain (presence of a helix- interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG)
- C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins
- contains 1 basic helix-loop-helix (bHLH) domain
- contains 1 Orange domain