transcription factor HES-7 (hairy & enhancer of split 7, bHLH factor Hes7, HES7)

Function

• transcriptional repressor
• represses transcription from both N box- & E box-containing promoters. May with HES1,
• cooperatively with HES1 regulates somite formation in presomitic mesoderm
• role as a segmentation clock, essential for coordinated somite segmentation

Structure

• contains 1 basic helix-loop-helix domain (bHLH)
• contains 1 Orange domain

Compartment

nucleus

More general terms

• transcriptional silencer (transcriptional repressor)
• hairy & enhancer of split (HES)

Database

• OMIM: https://mirror.omim.org/entry/608059
• UniProt: http://www.uniprot.org/uniprot/Q9BYE0.html