far upstream element-binding protein 1; FBP; FUSE-binding protein 1; DNA helicase V; hDH V (FUBP1)

Function

• regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter
• may act as transcriptional activator & transcriptional silencer
• ubiquitinated, targeting it for proteasome-mediated degradation
• found in a complex with PUF60 & far upstream element (FUSE) DNA segment
• interacts with PUF60 & JTV1

Structure

contains 4 KH domains

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

More general terms

• Far upstream element binding protein (FUSE binding protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8880
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8880
• OMIM: https://mirror.omim.org/entry/603444
• UniProt: http://www.uniprot.org/uniprot/Q96AE4.html