forkhead box protein C1; forkhead-related transcription factor 3; FREAC-3; drosophila forkhead homolog-like 7 (FOXC1, FREAC3)

Function

• binding to cognate site(s) results in bending of the DNA at an angle of 80-90 degrees

Structure

contains 1 fork-head DNA-binding domain

Expression

• expressed in all tissues & cell lines examined

Pathology

• defects in FOXC1 are a cause of Axenfeld-Rieger syndrome
• defects in FOXC1 are the cause of iridogoniodysgenesis anomaly
• defects in FOXC1 are a cause of Peters anomaly

More general terms

• forkhead family transcription factor

Database

• OMIM: https://mirror.omim.org/entry/601090
• UniProt: http://www.uniprot.org/uniprot/Q12948.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2296