protein atonal homolog 8 (Helix-loop-helix protein hATH-6, ATOH8, HATH6)

Function

• putative transcription factor
• may be implicated in specification & differentiation of neuronal cell lineages in the brain
• may participate in kidney development & may be involved in podocyte differentiation (putative)
• efficient DNA binding requires dimerization with another bHLH protein (putative)

Structure

contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in lung, liver, kidney, heart & pancreas
• expressed in endothelium of umbilical vessels

More general terms

• basic helix loop helix (bHLH) family transcription factor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8491
• UniProt: http://www.uniprot.org/uniprot/Q96SQ7.html