achaete-scute homolog 3 (bHLH transcriptional regulator Sgn-1, ASCL3, HASH3, SGN1)

Function

• transcriptional repressor
• inhibits myogenesis
• efficient DNA binding requires dimerization with another bHLH protein

Structure

contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus

Alternative splicing

named isoforms=1

Expression

• widely expressed in fetal & adult tissues

More general terms

• basic helix loop helix (bHLH) family transcription factor
• transcriptional silencer (transcriptional repressor)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NQ33.html