musculin; activated B-cell factor 1; ABF-1; class A basic helix-loop-helix protein 22; bHLHa22 (MSC, ABF1, BHLHA22)

Function

• transcription repressor capable of inhibiting the transactivation capability of TCF3/E47
• may play a role in regulating antigen-dependent B-cell differentiation efficient DNA binding requires dimerization with another bHLH protein
• binds DNA as a homodimer or a heterodimer
• forms a heterodimer with TCF3

Structure

• contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus

Expression

• expressed in lymphoid tissues, B-cell lines & activated B-cells

More general terms

• basic helix loop helix (bHLH) family transcription factor
• transcriptional silencer (transcriptional repressor)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9242
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9242
• OMIM: https://mirror.omim.org/entry/603628
• UniProt: http://www.uniprot.org/uniprot/O60682.html