myogenic factor MYF-6; herculin; myogenic factor 6 (MYF6)

Function

• role in muscle differentiation (myogenic factor)
• induces fibroblasts to differentiate into myoblasts
• probable sequence specific DNA-binding protein
• efficient DNA binding requires dimerization with another bHLH protein

Structure

contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus

Expression

Skeletal muscle

Pathology

• defects in MYF6 may be a cause of autosomal dominant myotubular myopathy

More general terms

• basic helix loop helix (bHLH) family transcription factor

Database

• UniProt: http://www.uniprot.org/uniprot/P23409.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4618
• OMIM: https://mirror.omim.org/entry/159991
• OMIM: https://mirror.omim.org/entry/160150
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4618