Krueppel-like factor 2; lung krueppel-like factor (KLF2, LKLF)

Function

• binds to the CACCC box in the beta-globin gene promoter & activates transcription (putative)
• ubiquitinated
• polyubiquitination involves WWP1 & leads to proteasomal degradation
• interacts with WWP1

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 3 C2H2-type Zn+2 fingers

Compartment

nucleus (putative)

More general terms

• Krueppel-like factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10365
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10365
• OMIM: https://mirror.omim.org/entry/602016
• UniProt: http://www.uniprot.org/uniprot/Q9Y5W3.html